ODCs

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1 associated gene
17 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 2

2 OMIM references -
4 associated genes
6 signs/symptoms

Osteosclerosis - developmental delay - craniosynostosis

Idiopathic juvenile osteoporosis


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	LRP5 LRP5	(0.65) (0.52)	DKK1 WNT1

Citations in the biomedical literature:

Osteosclerosis - developmental delay - craniosynostosis		Idiopathic juvenile osteoporosis
	Synonym(s): (no synonyms)		Synonym(s): - IJO - Juvenile osteoporosis

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 2 OMIM references - No MeSH references

Osteosclerosis - developmental delay - craniosynostosis		Idiopathic juvenile osteoporosis
	Very frequent - Autosomal dominant inheritance - Brachycephaly / flat occiput - Broad forehead - Dense / thickened skull / calvarium / cranial / facial hyperostosis - Enlargment of jaw / large jaw - High forehead - Hypertelorism - Macrocephaly / macrocrania / megalocephaly / megacephaly - Osteosclerosis / osteopetrosis / bone condensation Frequent - Craniostenosis / craniosynostosis / sutural synostosis Occasional - Cranial hypertension - Facial pain / cephalalgia / migraine - Facial palsy - Hearing loss / hypoacusia / deafness - Intellectual deficit / mental / psychomotor retardation / learning disability - Optic nerve anomaly / optic atrophy / anomaly of the papilla - Visual loss / blindness / amblyopia		Very frequent - Bone pain - Mutiple fractures / bone fragility - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets Frequent - Abnormal gait - Motor deficit / trouble Occasional - Kyphosis